Research Articles

53 | F. Huguet, E. Gokhan, H. A. Foster, H. A. Amin and P. Vagnarelli (2022) Repo-Man/PP1 SUMOylation mediates binding to lamin A and Serine 22 dephosphorylation.

Open Biology, in press

52 | R Sales-Gil, Dorothee C Kommer,I J. de Castro, H Amn, V Vinciotti, C Sisu, P Vagnarelli (2021) Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression.. EMBO Reports, e52061–18. DOI: 10.15252/embr.202052061.

51 | Ines J de Castro, Raquel Sales Gil, Lorena Ligammari, Maria Laura Di Giacinto, Paola Vagnarelli (2017) CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis Oncotarget 9(8): 7763–7773. Published online 2017 Dec 23. doi: 10.18632/oncotarget.23666

50 | Zhiteneva A, Bonfiglio JJ, Makarov A, Colby T, Vagnarelli P, Scirmer EC, Earnshaw WC (2017) Mitotic post-translational modifications of histones promote chromatin compaction in vitro. Open Biol. 2017 Sep;7(9). pii: 170076. doi: 10.1098/rsob.170076.

49 | I. de Castro, H. Amin, V. Vinciotti and P. Vagnarelli (2017). Network of phosphatases and HDAC complexes at repressed chromatin. Cell Cycle, 14:1-7. doi: 10.1080/15384101.2017.1371883

48 | Ineˆs J. de Castro, James Budzak, Maria L. Di Giacinto, Lorena Ligammari, EzgiGokhan, Christos Spanos, Daniela Moralli, Christine Richardson, Jose I. de las Heras, Silvia Salatino, Eric C. Schirmer, Katharine Ullman, Wendy Bickmore, Catherine Green, Juri Rappsilber, Sarah Lamble, Martin W. Goldberg, Veronica Vinciotti & Paola Vagnarelli (2017) Repo-Man/PP1 regulates heterochromatin formation in interphase. Nature Communications DOI: 10.1038/ncomms14048

47 | Gabriele Corda, Gianluca Sala, Rossano Lattanzio, Manuela Iezzi, Michele Sallese, Giorgia Fragassi, Alessia Lamolinara, Hasan Mirza, Daniela Barcaroli, Sibylle Ermler, Elisabete Silva, Hemad Yasaei, Robert F. Newbold, Paola Vagnarelli, Marcella Mottolese, Pier Giorgio Natali, Letizia Perracchio, Jelmar Quist, Anita Grigoriadis, Pierfrancesco Marra, Andrew N Tutt, Mauro Piantelli, Stefano Iacobelli, Vincenzo De Laurenzi, Arturo Sala (2016). Functional and prognostic significance of the genomic amplification of frizzled receptor 6 (FZD6) in breast cancer. The Journal of pathology, DOI: 1002/path.4841

46 | Martin CA, Murray JE, Carroll P, Leitch A, Mackenzie KJ, Halachev M, Fetit AE, Keith C, Bicknell LS, Fluteau A, Gautier P, Hall EA, Joss S, Soares G, Silva J, Bober MB, Duker A, Wise CA, Quigley AJ, Phadke SR; Deciphering Developmental Disorders Study., Wood AJ, Vagnarelli P, Jackson AP. (2016) Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Genes Dev. 2016 Oct 1;30(19):2158-2172.

45 | Kumar GS, Gokhan E, De Munter S, Bollen M, Vagnarelli P, Peti W, Page R. (2016) The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism. Elife. 2016 Aug 30;5. pii: e16539. doi: 10.7554/eLife.16539.

44 | Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC, Vagnarelli P. Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.(2014) Elife. 27;3:e01641. doi: 10.7554/eLife.01641.

43 | Ribeiro SA, Vagnarelli P, Earnshaw WC. DNA content of a functioning chicken kinetochore.(2014) Chromosome Res. 22(1):7-13. doi: 10.1007/s10577-014-9410-3.

42 | Vagnarelli P. Chromatin reorganization through mitosis. (2013) Adv Protein Chem Struct Biol. 2013;90:179-224. doi: 10.1016/B978-0-12-410523-2.00006-7.

41 | Samejima K, Samejima I, Vagnarelli P, Ogawa H, Vargiu G, Kelly DA, de Lima Alves F, Kerr A, Green LC, Hudson DF, Ohta S, Cooke CA, Farr CJ, Rappsilber J, Earnshaw WC. (2012) J Cell Biol. 199(5):755-70. doi: 10.1083/jcb.201202155.

40 | Vagnarelli P and Earnshaw WC. (2012) Repo-Man/PP1: a link between chromatin remodeling and nuclear envelope reassembly. Nucleus, 3:1-5. Corresponding Author

39 | Lydia C Green, Paul Kalitsis, Tsz M Chang, Miri Cipetic, Ji Hun Kim, Owen Marshall, Lynne Turnbull, Cynthia B Whitchurch, Paola Vagnarelli, Kumiko Samejima, William C Earnshaw, K H Andy Choo, Damien F Hudson (2011) Contrasting roles of condensin I and II in mitotic chromosome formation. Journal of Cell Science, in press.

38 | Vagnarelli P*, Ribeiro S, Sennels L, Sanchez-Pulido L, de Lima Alves F, Verheyen T, Kelly DA, Ponting CP, Rappsilber J, Earnshaw WC. (2011) Repo-Man Coordinates Chromosomal Reorganization with Nuclear Envelope Reassembly during Mitotic Exit. Dev Cell. 21(2):328-42. *Co-corresponding Author

37 | Zhenjie Xu, Paola Vagnarelli, Hiromi Ogawa, Kumiko Samejima, and William C. Earnshaw (2010) Gradient of Increasing Aurora B Kinase Activity Is Required for Cells to Execute Mitosis J. Biol. Chem. 2010 285: 40163-40170. (Journal Cover by P.Vagnarelli)

36 | S.Ribeiro, P.Vagnarelli, Y.Dond, T.Hori, B.McEwen, T. Fukagawa, C.Flors and W. Earnshaw (2010). A super-resolution map of the vertebrate kinetochore. PNAS, 107(23):10484-9

35 | A.Mocciaro, E.Berdougo , E.Black, P.Vagnarelli, W.Earnshaw, D.Gillespie, P.Jallepalli, and E.Schiebel (2010) Cells deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired for DNA repair. JCB, 17;189(4):631-9.

34 | Z.Xu, H.Ogawa, P.Vagnarelli, J.Bergmann, D.F.Hudson, S.Ruchaud, T.Fukagawa, W.C.Earnshaw and K.Samejima (2009) INCENP-Aurora B interactions modulate kinase activity and chrmosome passenger complex localisation. J. Cell Biol.187:637-53

33 | Ribeiro SA, Gatlin JC, Dong Y, Joglekar A, Cameron L, Hudson DF, Farr CJ, McEwen BF, Salmon ED, Earnshaw WC, and Vagnarelli P. (2009) Condensin regulates the stiffness of vertebrate centromeres. Mol Biol Cell. 20(9):2371-80. Last Author and Corresponding Author

32 | Y.Dong, P.Vagnarelli, X.Meng, S.Ribeiro, W.C.Earnshaw and B.F.McEwen (2008) Localizing kinetochores in Condensin deficient DT40 cells using same cel correlative confocal light microscopy/electron tomography. Microsc Microanal 1070-71.

31 | Nakano M, Cardinale S, Noskov VN, Gassmann R, Vagnarelli P, Kandels-Lewis S, Larionov V, Earnshaw WC, Masumoto H. (2008) Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell. 14(4):507-22.

30 | Samejima K., Ogawa H., Cooke C.A., Hudson D.F., MacIsaac F., Ribeiro S.A, Vagnarelli P., Cardinale S., Kerr A.,Lai F., Ruchaud S., Yue Z. and Earnshaw W.C.(2008). A novel promoter-hijack strategy for conditional knockouts of multiple spliced essential cell cycle genes. PNAS, 105 (7):2457-62

29 | Griffith E., Walker S.,Martin C.A., Vagnarelli P., Stiff T., Vernay B.,Al Sanna N, Saggar A, Hamel B, Earnshaw W.C, Jego P.A, Jackson A.P. and O’Driscoll M. (2007) Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics, 40 2):232-6

28 | Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA. (2007) Chk1 is required for spindle checkpoint function. Dev Cell. 12(2):247-60.

27 | Vagnarelli P, Hudson DF, Ribeiro SA, Trinkle-Mulcahy L, Spence JM, Lai F, Farr CJ, Lamond AI, Earnshaw WC (2006) Condensin and RepoMan-PP1 co-operate in the regulation of chromosome architecture during mitosis. Nat Cell Biol. 2006 Oct;8(10):1133-42.

26 | Regnier V., Vagnarelli P., Fukagawa T., Zerjal T., Burns E., Trouche D., Earnshaw W.C. and Brown W. (2005) CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1. Mol.Cell Biol 25:3967-81.

25 | Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C. (2004). Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J., 23: 3864-73.

24 | Vagnarelli P, Morrison C, Dodson H, Sonoda E, Takeda S, Earnshaw WC (2004). Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores. EMBO Rep.,5:167-71.

23 | Regnier V, Novelli J, Fukagawa T, Vagnarelli P, Brown W. (2003) Characterization of chicken CENP-A and comparative sequence analysis of vertebrate centromere-specific histone H3-like proteins. Gene;316: 39-46.

22 | Hudson D*,Vagnarelli P.*, Gassmann R. and William C. Earnshaw (2003) ScII/SMC2 is required for normal scaffold formation and structural integrity of vertebrate mitotic chromosomes. Dev Cell 5:323-336.* equal first authors

21 | Morrison C., Vagnarelli P., Sonoda E, Takeda S, Earnshaw WC (2003) Sister chromatid cohesion and genome stability in vertebrate cells. Biochem Soc Trans 31:263-5

20 | Jullien D., Vagnarelli P., Earnshaw W.C. and Adachi Y. (2002) Kinetochore localisation of the DNA damage response component 53BP during mitosis. Journal of cell science 115:71-79

19 | Moralli D., Vagnarelli P., Bensi M., De Carli L. and Raimondi E. (2001) Insertion of a loxP site in a size-reduced human accessory chromosome. Cytogenet. And Cell Genet 94:113-120.

18 | Sonoda E., Matsusaka T., Morrison C., Vagnarelli P., Hoshi O., Usihiki T., Nojima K., Fukagawa T., Waizenegger I.C., Peters J.M., Earnshaw W.C. and Takeda S. (2001) Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in Vertebrate cells. Dev Cell 1:759-770. (Journal Cover by P.Vagnarelli)

17 | Vagnarelli P. and Earnshaw W.C. (2001) INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion. Chromosoma 110:393-401.

16 | Adams R., Eckley D.M., Vagnarelli P., Wheatley S.P., Gerloff D.L., Mackay A.M., Svingen P.A., Kaufmann S.H. and Earnshaw W.C (2001) Human INCENP colocalizes with the Auora-B/AIRK2 kinase on chromosomes and is overexpressed in tumor cells. Chromosoma 110:65-74

15 | Wheatly S.P., Carvalho A., Vagnarelli P. and Earnshaw W.C. (2001) INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Current Biology 11:886-890.

14 | Raimondi E., Balzaretti M., Moralli D.,Vagnarelli P.,Tredici F., Bensi M. and De Carli L. (1996). Gene targeting to the centromere of a human minichromosome. Human Gene Therapy, 7: 1103-1109

13 | Vagnarelli P., Raimondi E., Coelli C., Fattorini P., Dorigo E. and De Carli L. (1996) DNA fingerprint analysis for the detection of induced mutations in mammalian cells in culture. Cytotechnology, 19: 137-142.

12 | Raimondi, E., Moralli, D., Vagnarelli, P., Balzaretti, M and De Carli, L.(1994): Human minichromosomes as potential vectors for gene therapy. J. Exp. Clin. Cancer Res., 14: 207-209.

11 | Mazzieri, R., Høyer-Hansen, G., Rønne, E., Løber, D., Vagnarelli, P., Raimondi, E., De Carli, L., Danø, K. and Mignatti, P.(1994): Urokinase and urokinase receptor expression in somatic cell hybrids. Fibrinolysis 8: 344-352.

10 | Vagnarelli P., Giulotto E., Fattorini P., Mucciolo E., Bensi M., Tessera L. and De Carli L. (1993) Variation of minisatellites in chemically induced mutagenesis and in gene amplification. In “DNA fingerprinting: State of the Science” S.D.J.Pena, R.Chakraborty, J.T.Epplen and A.J.Jeffreys Eds., Birkhauser Verlag Basel, Switzerland, pp72-77.

9 | Casati A., Giorgi R., Lanza A., Raimondi E., Vagnarelli P., Mondello C., Ghetti P., Piazzi G. and Nuzzo F.. (1992) Trisomy 21 mosaicism in two subjects from two generations. Annales de Genetique 35: 245-250.

8 | Vagnarelli P., Raimondi E., Mazzieri R., De Carli L. and Mignatti P. (1992) Assignment of the Human Urokinase Receptor (PLAUR) gene to 19q13. Cytogenet. Cell Genet. 60: 197-199.

7 | Vagnarelli P., De Sario A., Cuzzoni M.T., Mazza P.G. and De Carli L.. (1991). Cytotoxicity and clastogenic activity of Ribose-lysine browning model system. J. Agricultural and food chemistry 39: 2237-2239

6 | Vagnarelli P., De Sario A. and De Carli L. (1990) Aneuploidy induced by chloral hydrate detected on human lymphocytes with the Y97 probe. Mutagenesis, 5: 591-592.

5 | De Sario A., Vagnarelli P. and De Carli L. (1990). Aneuploidy assay on diethylstilbestrol by means of in situ hybridization of radioactive and biotinylated probes on interphase nuclei. Mutation research 243:127-131.

4 | Vagnarelli P., De Sario A., Raimondi E., Scariolo S. and De Carli L. (1989) Use of interphase analysis to detect chemically induced aneuploidy in cultured cells. Environmental and molecular mutagenesis 14:204-205.

3 | Raimondi E., Vagnarelli P., Bensi M. and De Carli L. (1989). Characterisation of an X-X translocation by cytological analysis and in situ hybridisation. Cytogenetics and Cell Genetics. 50:123-124.

2 | E.Raimondi, S.Scariolo, P.Vagnarelli, A.De Sario and L.De Carli (1987). Detection of chromosome variation in interphase by in situ hybridization with repetitive DNA probes: potential applications to cytogenetic analysis and mutagenicity testing. Cytotechnology 1:13-17.

1 | G.Gazzani, P.Vagnarelli, M.T.Cuzzoni and P.G.Mazza (1987). Mutagenic activity of the Maillard reaction products of Ribose with different amino acids. Journal of Food Science. 52 (3): 757-760

Reviews and Book Chapters

16 | Stamatiou K and Vagnarelli P (2021) Chromosome Clustering in mitosis by nuclear protein Ki-67. Biochem Soc Trans,

15 | Vagnarelli P (2021) Back to the new beginning: Mitotic exit in space and time. Semin Cell Dev Biol S1084-9521(21)00042-2 DOI: 10.1016/j.semcdb.2021.03.010

14 | Huguet F, Flynn S, Vagnarelli P. The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies. Cells. 2019 Jul 7;8(7). pii: E687. doi: 10.3390/cells8070687.

13 | Sales Gil R and Vagnarelli P (2020) How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance . Cells 2020, 9, 1460; doi:10.3390/cells9061460

12 | Vagnarelli P, Alessi DR (2018) PP1 Phosphatase Complexes: Undruggable No Longer. Cell. 2018 Aug 23;174(5):1049-1051. doi: 10.1016/j.cell.2018.08.007.

11 | Sales Gil R, Vagnarelli P. (2018) Ki-67: More hidden behind a “Classic proliferation marker” Trends Biochem Sci. 2018 Oct;43(10):747-748. doi: 10.1016/j.tibs.2018.08.004.

10 | Raquel Sales Gil and Paola Vagnarelli (2018). Protein Phosphatases in chromatin structure and function. Biochim Biophys Acta Mol Cell Res. 2018 Jul 20. pii: S0167-4889(18)30200-3. doi:10.1016/j.bbamcr.2018.07.016.

9 | Raquel Sales Gil, Ines J. de Castro, Jerusalem Berihun, Paola Vagnarelli (2018). Protein phosphatases at the nuclear envelope Biochem Soc Trans. 46(1): 173–182. doi: 10.1042/BST20170139.

8 | de Castro IJ, Gokhan E, Vagnarelli P. (2016). Resetting a functional G1 nucleus after mitosis. Chromosoma. DOI 10.1007/s00412-015-0561-6

7 | Vagnarelli P. Repo-man at the intersection of chromatin remodelling, DNA repair, nuclear envelope organization, and cancer progression. (2014) Adv Exp Med Biol. 773:401-14. doi: 10.1007/978-1-4899-8032-8_18.

6 | Meadows JC, Graumann K, Platani M, Schweizer N, Shimi T, Vagnarelli P, Gatlin JC. Meeting report: mitosis and nuclear structure. (2013) J Cell Sci. 2013 126(Pt 22):5087-90. doi: 10.1242/jcs.142950.

5 | Vagnarelli P. (2012). Chromosome Condensation in vertebrates. Experimental Cell Research, In Press.

4 | Paulson J.R. and Vagnarelli P. (2011) Chromosomes and Chromatin in Encyclopedia of Life Sciences.

3 | Vagnarelli P, Ribeiro SA, Earnshaw WC. (2008) Centromeres: old tales and new tools. FEBS Lett. 582(14):1950-9. Corresponding Author

3 | Gassmann R, Vagnarelli P, Hudson D, Earnshaw WC. (2004). Mitotic chromosome formation and the condensin paradox. Exp Cell Res,15: 35-42.

2 | Vagnarelli P, Earnshaw WC. (2004). Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma. 2004:211-22.

1 | Craig J.M., Earnshaw W.C. and Vagnarelli P. (1999) Mammalian centromeres: DNA sequences, protein composition and role in cell cycle progression. Experimental Cell research, review 246:249-262.